Glycomimetic Based Approach toward Selective Carbonic Anhydrase Inhibitors
نویسندگان
چکیده
منابع مشابه
Novel Sulfamide-Containing Compounds as Selective Carbonic Anhydrase I Inhibitors.
The development of isoform selective inhibitors of the carbonic anhydrase (CA; EC 4.2.1.1) enzymes represents the key approach for the successful development of druggable small molecules. Herein we report a series of new benzenesulfamide derivatives (-NH-SO₂NH₂) bearing the 1-benzhydrylpiperazine tail and connected by means of a β-alanyl or nipecotyl spacer. All compounds 6a-l were investigated...
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ژورنال
عنوان ژورنال: ACS Medicinal Chemistry Letters
سال: 2020
ISSN: 1948-5875,1948-5875
DOI: 10.1021/acsmedchemlett.9b00590